Treatment choices for male infertility depend on the results of semen analysis. Lifestyle changes, hormonal therapy, or resolution of the underlying condition is effective in most cases. Your doctor may choose to extract sperm from the testicles or do the required surgery. Other treatments are insemination and in vitro fertilization. In certain cases, your physician may suggest taking the assistance of a sperm donor. A sperm DNA fragmentation test will give further insight into the sperm quality and is a better predictor of ART treatment outcomes.