Sperm DNA fragmentation is higher in infertile men compared to fertile men. The genetic material within the sperm is tightly packaged, but susceptible to damage and breaks by various means. The structure of the DNA could be imagined as a ladder made up of side rails and rungs. If there is a break in either the rungs or the side rails, the ladder is unsteady and cannot function properly. Such breaks in the DNA of the sperm is referred to as Sperm DNA Fragmentation and can lead to impaired sperm function resulting in unsuccessful pregnancies.